- Mike Henry - Cleveland Brown, Rallo Tubbs
- Sanaa Lathan - Donna Tubbs-Brown
- Jason Sudeikis - Holt Richter, Terry Kimple in Kenny West
- Will Forte - Cleveland Brown Jr.
- Kevin Michael Richardson - Federline Jones, Lester Krinklesac
- Reagan Gomez-Preston - Roberta Tubbs
- Seth Green - Chris Powell
- Alex Borstein - Tricia Takanawa, Lois Griffin, Barbara
- Arianna Huffington - Arianna Huffington
- Jamie Kennedy - Robert
- Corey Holcomb - Kenny Loggins
- David Lynch - Gus
- Gilbert Gottfried - The Cryptkeeper
- Patrick Stewart - sam